NVS-ZP7-4

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NVS-ZP7-4

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Cat No: 33773

Biochemicals - More Biochemicals

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).{62162} It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 µM) ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4?(1?H)-quinazolin]-2?(3?H)-one

Correlated keywords:

NVSZP74 NVSZP7 ZP74 ZIP-7 SLC39-A7 SLC-39A7 TALL1 MDAMB231 MDAMB MB231 RCC-4 U-2 OS

Product Overview:
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7).{62162} It induces apoptosis in TALL-1 human T cell acute lymphoblastic leukemia cells, an effect that can be reduced by expression of the ZIP7 point mutant ZIP7V430E. NVS-ZP7-4 (20 µM) increases endoplasmic reticulum, but not cytosolic, zinc levels in U2OS cells. It inhibits ferroptosis induced by erastin (Item No. 17754) in MDA-MB-231 and RCC4 cells when used at a concentration of 10 µM.{62163}

Size	1 mg
Shipping	dry ice
CAS Number	2349367-89-9
Molecular Formula	C₂₈H₂₈FN₅OS
SMILES	O=C1NC2(CCN(CC2)C[C@H](CC3=CC=CC=C3)NC4=NC5=CC=C(F)C=C5S4)C6=CC=CC=C6N1
Molecular Weight	501,6
Formulation	A solid
Purity	≥98%
Custom Code	2934.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.