Myrislignan

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Myrislignan

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Cat No: 33759

Biochemicals - Natural Products

Myrislignan is a lignan that has been found in M. fragrans and has diverse biological activities.{54917,54918,54919,54920} It inhibits hypocotyl or root growth of cress (IC50s = 429 and 517 µM, respectively).{54917} Myrislignan (50 µg/ml) inhibits pro...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?R-[(1S)-1-[2,6-dimethoxy-4-(2-propen-1-yl)phenoxy]ethyl]-4-hydroxy-3-methoxy-benzenemethanol

Correlated keywords:

Myristica COX2 TNF? IL6 A 549 Toxoplasma

Product Overview:
Myrislignan is a lignan that has been found in M. fragrans and has diverse biological activities.{54917,54918,54919,54920} It inhibits hypocotyl or root growth of cress (IC50s = 429 and 517 µM, respectively).{54917} Myrislignan (50 µg/ml) inhibits production of nitric oxide (NO), increases in inducible nitric oxide synthase (iNOS) and COX-2 levels, and release of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells.{54918} It inhibits the proliferation of, and induces apoptosis in, A549 lung cancer cells.{54919} Myrislignan (3, 5, and 8 mg/kg) reduces tumor growth in an A549 lung cancer mouse xenograft model. It decreases parasite burden in the liver, brain, and spleen in a mouse model of T. gondii infection when administered at a dose of 100 mg/kg.{54920}

Size	5 mg
Shipping	dry ice
CAS Number	171485-39-5
Molecular Formula	C₂₁H₂₆O₆
SMILES	O[C@H](C1=CC(OC)=C(C=C1)O)[C@H](C)OC2=C(C=C(C=C2OC)CC=C)OC
Molecular Weight	374,4
Formulation	A solid
Purity	≥98%
Custom Code	2909.50
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.