Pachymic Acid

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Pachymic Acid

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Cat No: 33180

Biochemicals - Kinase Inhibitors

Pachymic acid is a triterpenoid that has been found in P. cocos and has diverse biological activities.{59935,59936,59937,59938} It inhibits hexokinase 2 (HK2; IC50 = 5.01 µM), as well as reduces glucose uptake and lactate production in SK-BR-3 breast ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3?-(acetyloxy)-16?-hydroxy-24-methylene-lanost-8-en-21-oic acid

Correlated keywords:

Poria SKBR3 549 NCIH23 NSC244427 IL1?

Product Overview:
Pachymic acid is a triterpenoid that has been found in P. cocos and has diverse biological activities.{59935,59936,59937,59938} It inhibits hexokinase 2 (HK2; IC50 = 5.01 µM), as well as reduces glucose uptake and lactate production in SK-BR-3 breast cancer cells.{59935} Pachymic acid inhibits IL-1β-induced cytosolic phospholipase A2 (cPLA2) activation and prostaglandin E2 (PGE2; Item No. 14010) production in, as well as inhibits the proliferation of, A549 lung cancer cells.{59936} It decreases tumor growth in an NCI H23 lung cancer mouse xenograft model when administered at doses of 30 and 60 mg/kg.{59937} Pachymic acid (10 and 20 mg/kg) prevents increases in serum urea and creatinine levels in a mouse model of renal ischemia-reperfusion injury.{59938}

Size	5 mg
Shipping	dry ice
CAS Number	29070-92-6
Molecular Formula	C₃₃H₅₂O₅
SMILES	C[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)OC(C)=O)C)C
Molecular Weight	528,8
Formulation	A solid
Purity	≥98%
Custom Code	2918.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.