Cytostatin

Cytostatin

CAT N°: 32891
Price:

650.00 552.50

Cytostatin is a bacterial metabolite that has been found in Streptomyces and has enzyme inhibitory and anticancer activities.{31269,31268} It inhibits protein phosphatase 2A (PP2A; IC50 = 0.09 µg/ml) and is selective for PP2A over PP1, PP2B, and alkaline phosphatase at 100 µg/ml.{31269} Cytostatin inhibits the adhesion of B16/F10 murine melanoma cells to laminin and type IV collagen (IC50s = 1.3 and 1.4 µg/ml, respectively).{31268} In vivo, cytostatin (1.25 mg/kg, i.p.) reduces the number of lung metastases in a B16/F10 murine melanoma model.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5S,6S)-5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one
  • Correlated keywords
    • 156856-30-3 791036-11-8 794469-08-2 NSC675266 MJ654NF4 anti-cancer PP-2A PP2-A PP-1 PP2-B PP-2B
  • Product Overview:
    Cytostatin is a bacterial metabolite that has been found in Streptomyces and has enzyme inhibitory and anticancer activities.{31269,31268} It inhibits protein phosphatase 2A (PP2A; IC50 = 0.09 µg/ml) and is selective for PP2A over PP1, PP2B, and alkaline phosphatase at 100 µg/ml.{31269} Cytostatin inhibits the adhesion of B16/F10 murine melanoma cells to laminin and type IV collagen (IC50s = 1.3 and 1.4 µg/ml, respectively).{31268} In vivo, cytostatin (1.25 mg/kg, i.p.) reduces the number of lung metastases in a B16/F10 murine melanoma model.

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