IRL 1620 (trifluoroacetate salt)

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Cat No: 30980

Biochemicals - Receptor Pharmacology

IRL 1620 is a peptide endothelin type B (ETB) receptor agonist.{60959} It selectively binds to ETB receptors (Ki = 16 pM) over ETA receptors (IC50 = 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging fro...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(3-carboxy-1-oxopropyl)-L-?-aspartyl-L-?-glutamyl-L-?-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-?-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan, trifluoroacetate salt

Correlated keywords:

154205-39-7 142569-99-1 IRL1620 SPI1620 Sovateltide PMZ1620

Product Overview:
IRL 1620 is a peptide endothelin type B (ETB) receptor agonist.{60959} It selectively binds to ETB receptors (Ki = 16 pM) over ETA receptors (IC50 = 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging from 0.01 to 1 µM. IRL 1620 (1 nmol/kg) reduces mean arterial pressure (MAP) in normotensive rats and spontaneously hypertensive rats (SHRs) and diminishes the transient depressor response in SHRs.{60960} It reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia.{60961} IRL 1620 also improves spatial memory deficits induced by amyloid-β (Aβ) in a rat model of Alzheimer's disease.

Size	500 µg
Shipping	dry ice
Molecular Formula	C₈₆H₁₁₇N₁₇O₂₇ • XCF₃COOH
SMILES	OC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C=C2)
Molecular Weight	1820,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2924.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.