(R)-Mephenytoin

(R)-Mephenytoin

CAT N°: 25891
Price:

From 49.00 41.65

(R)-Mephenytoin is the (R) enantiomer of the anticonvulsant mephenytoin.{47078} (R)-Mephenytoin can be demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the active metabolite 5-ethyl-5-phenylhydantoin (nirvanol).{47079,23860} The ratio of (S)-mephenytoin (Item No. 11913) to (R)-mephenytoin in urine following administration of the racemic mixture has been used to detect polymorphisms in drug metabolism by CYP2C19, as only (S)-mephenytoin is a substrate of CYP2C19.{23861,23857,47079}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5R)-5-ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
  • Correlated keywords
    • anti-convulsant P 450 CYP 2C9 mesantoin CYP450 2C19
  • Product Overview:
    (R)-Mephenytoin is the (R) enantiomer of the anticonvulsant mephenytoin.{47078} (R)-Mephenytoin can be demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the active metabolite 5-ethyl-5-phenylhydantoin (nirvanol).{47079,23860} The ratio of (S)-mephenytoin (Item No. 11913) to (R)-mephenytoin in urine following administration of the racemic mixture has been used to detect polymorphisms in drug metabolism by CYP2C19, as only (S)-mephenytoin is a substrate of CYP2C19.{23861,23857,47079}

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