N-Ethylmaleimide

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N-Ethylmaleimide

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Cat No: 19938

Biochemicals - Ion Channel Modulation

N-Ethylmaleimide is a modifier of sulfhydryl groups in proteins.{60591,60592} It has commonly been used to inactivate cysteine-containing enzymes in vitro. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 µM.{60593} It alkylate...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

Special Advice: Dangerous Good in said quantity, not available for sale.

Synonyms:

1-ethyl-1H-pyrrole-2,5-dione

Correlated keywords:

Maleic acid N-ethylimide NSC7638 Ethyl-maleimide Cys-519

Product Overview:
N-Ethylmaleimide is a modifier of sulfhydryl groups in proteins.{60591,60592} It has commonly been used to inactivate cysteine-containing enzymes in vitro. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC50 value of 6.3 µM.{60593} It alkylates cysteine 519 (Cys519) in voltage-gated potassium channel 7.4 (Kv7.4) and activates Kv7.2 , Kv7.4, and Kv7.5, but not Kv7.3, in CHO cells expressing the human channels when used at a concentration of 50 µM.{60594}

Size	25 g
Shipping	dry ice
CAS Number	128-53-0
Molecular Formula	C₆H₇NO₂
SMILES	O=C1C=CC(N1CC)=O
Molecular Weight	125,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.