LTX-315 (trifluoroacetate salt)

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Cat No: 19901

Biochemicals - More Biochemicals

LTX-315 is a synthetic cationic amphiphilic peptide.{58779} It is cytotoxic to a variety of human cancer cell lines, including A20 lymphoma and AT-84 squamous cell carcinoma cells (IC50s = 8.3 and 11 µM, respectively), and to non-cancerous MRC-5 fibro...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-lysyl-L-lysyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-lysyl-L-tryptophyl-β-phenyl-L-phenylalanyl-L-lysinamide, trifluoroacetate salt

Correlated keywords:

1345407-05-7 LTX315 cyto toxic AT84 MRC5 fibro blast IL1β IL6 intra tumoral Ruxotemitide

Product Overview:
LTX-315 is a synthetic cationic amphiphilic peptide.{58779} It is cytotoxic to a variety of human cancer cell lines, including A20 lymphoma and AT-84 squamous cell carcinoma cells (IC50s = 8.3 and 11 µM, respectively), and to non-cancerous MRC-5 fibroblasts (IC50 = 34.3 µM) but not human red blood cells (EC50 = >695 µM).{58780} LTX-315 is also cytotoxic to drug-sensitive and -resistant cancer cell lines (IC50s = 2.1-6.4 and 2.5-3.2 µM, respectively). It permeabilizes mitochondrial membranes and induces immunogenic cell death in tumor cells in vitro.{58781,58779} Intratumoral administration of LTX-315 (1 mg peptide/50 µl saline) increases tumor levels of IL-1β and IL-6 and induces necrosis in, and complete regression of, tumors in a B16/F1 syngeneic mouse model of melanoma.{58782}

Size	5 mg
Shipping	dry ice
Molecular Formula	C₇₈H₁₀₆N₁₈O₉ • XCF₃COOH
SMILES	O=C([C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@@H](NC([C@@H](NC([C@H](CC5=CNC6=CC=CC=C65)NC([C@H](CC7=CNC8=CC=CC=C78)NC([C@@H](NC([C@H](CCCCN)N)=O)CCCCN)=O)=O)=O)CCCCN)=O)CCCCN)=O)=O)N[C@@H](CCCCN)C(N)=O.OC(C(F)(F)F)=O
Molecular Weight	1439,8
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.