Gallein

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Gallein

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Cat No: 16344

Biochemicals - Ox Stress Reagents

Gallein is an inhibitor of G protein βγ subunit-dependent signaling.{61667} It binds to Gβ1γ2 in a cell-free assay (IC50 = 200 nM) and inhibits Gβγ-dependent activation of PI3K in HL-60 cells. Gallein (10 µM) also inhibits Rac1 activation, superoxide ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3?,4?,5?,6?-tetrahydroxy-spiro[isobenzofuran-1(3H),9?-[9H]xanthen]-3-one

Correlated keywords:

52413-?17-?9 Alizarine violet CI 45445 C.I.45445 CI45445 Mordant Violet 25 NSC56445 NSC622478 NSC 8668 Pyrogallolphthalein G?-1?2 ? P13-K P-13K HL60 Rac-1 f-MLP

Product Overview:
Gallein is an inhibitor of G protein βγ subunit-dependent signaling.{61667} It binds to Gβ1γ2 in a cell-free assay (IC50 = 200 nM) and inhibits Gβγ-dependent activation of PI3K in HL-60 cells. Gallein (10 µM) also inhibits Rac1 activation, superoxide production, and chemotaxis induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in differentiated HL-60 cells. In vivo, gallein (10 mg/kg per day) increases survival, reduces ventricular hypertrophy, and attenuates cardiac remodeling in a mouse model of heart failure induced by transverse aortic constriction (TAC).{61668}

Size	50 mg
Shipping	dry ice
CAS Number	2103-64-2
Molecular Formula	C₂₀H₁₂O₇
SMILES	OC1=C(O)C2=C(C=C1)C3(C(C=CC=C4)=C4C(O3)=O)C5=CC=C(O)C(O)=C5O2
Molecular Weight	364,3
Formulation	A solid
Purity	≥95%
Custom Code	2918.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.