Paraxanthine-d6

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Paraxanthine-d₆

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Cat No: 9003564

Biochemicals - Isotopically Labeled Standards

Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine (Item No. 21068) by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine (Item No. 14118).{58128} It is formed via N3-demethylation of caffein...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,7-dihydro-1,7-di(methyl-d3)-1H-purine-2,6-dione

Correlated keywords:

deuterated deuterium GCMS LCMS Paraxanthined6 N3demethylation P 450 CPY 1A2 A 1 2 c GMP N6cyclopentyladenosine CGS21680 17Dimethylxanthined6

Product Overview:
Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine (Item No. 21068) by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine (Item No. 14118).{58128} It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively).{38151} In vivo, paraxanthine (30 mg/kg) increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA (N6-cyclopentyladenosine; Item No. 21448) or the adenosine A2 receptor agonist CGS 21680 (Item No. 17126) in rats not habituated to caffeine.{38150} It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.{38152}

Size	500 µg
Shipping	dry ice
CAS Number	117490-41-2
Molecular Formula	C₇H₂D₆N₄O₂
SMILES	O=C1C2=C(N=CN2C([2H])([2H])[2H])NC(N1C([2H])([2H])[2H])=O
Molecular Weight	186,2
Formulation	A crystalline solid
Purity	≥99% deuterated forms (d1-d6); ?1% d0
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.