Covidyte™ ED450

CAT N°: 33767
Price:

420.00 357.00

Viral main protease (Mpro), also known as 3C-like protease (3CLpro), is a viral protease that mediates the replication and transcription of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, the causative agents of SARS and COVID-19, respectively.{54840,54841} Mpro digests SARS-CoV and SARS-CoV-2 viral polyproteins at 11 conserved sites, beginning with autolytic cleavage of itself, to release the functional peptides required for viral replication and transcription. Covidyte™ ED450 is a fluorogenic substrate for Mpro that contains 12 amino acids, VNSTLQSGLRKM, which are recognized by Mpro. Upon enzymatic cleavage by Mpro, EDANS is separated from the Dabcyl quencher, displays excitation/emission maxima of 336/455 nm, respectively, and can be used to quantify Mpro activity.

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • ED-450 SARSCoV2 SARSCoV covid19 coronavirus
  • Product Overview:
    Viral main protease (Mpro), also known as 3C-like protease (3CLpro), is a viral protease that mediates the replication and transcription of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, the causative agents of SARS and COVID-19, respectively.{54840,54841} Mpro digests SARS-CoV and SARS-CoV-2 viral polyproteins at 11 conserved sites, beginning with autolytic cleavage of itself, to release the functional peptides required for viral replication and transcription. Covidyte™ ED450 is a fluorogenic substrate for Mpro that contains 12 amino acids, VNSTLQSGLRKM, which are recognized by Mpro. Upon enzymatic cleavage by Mpro, EDANS is separated from the Dabcyl quencher, displays excitation/emission maxima of 336/455 nm, respectively, and can be used to quantify Mpro activity.

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