4-hydroxy Estrone

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4-hydroxy Estrone

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Cat No: 33696

Biochemicals - Lipids

4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone (Item No. 10006485).{57564} It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocati...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,4-dihydroxy-estra-1,3,5(10)-trien-17-one

Correlated keywords:

Hydroxyestrone P-450 1B1 1A2 1A1 p-53 HT-22 MCF7 MDAMB231 MDAMB MB231

Product Overview:
4-hydroxy Estrone is a metabolite of the endogenous estrogen estrone (Item No. 10006485).{57564} It is formed from estrone primarily by the cytochrome P450 (CYP) isoforms CYP1B1, CYP1A2, and CYP1A1. 4-hydroxy Estrone (5 µM) induces nuclear translocation of phosphorylated p53 and is protective against glutamate-induced oxidative death in HT22 hippocampal neuronal cells.{57565} It reduces neurodegeneration induced by kainic acid in the rat hippocampus and improves working memory in the Y-maze in rats when administered at a dose of 10 µg/animal. 4-hydroxy Estrone also inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer cells with IC50 values of 30 and 38 µM, respectively.{28444}

Size	1 mg
Shipping	dry ice
CAS Number	3131-23-5
Molecular Formula	C₁₈H₂₂O₃
SMILES	C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3
Molecular Weight	286,4
Formulation	A solid
Purity	≥95%
Custom Code	2937.23
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.