SARS-CoV-2 Surface Glycoprotein Rabbit Monoclonal Neutralizing Antibody (Clone 004)

SARS-CoV-2 Surface Glycoprotein Rabbit Monoclonal Neutralizing Antibody (Clone 004)

CAT N°: 33627
Price:

847.00 719.95

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.{53462,53459,53461,55257,55258} The SARS-CoV-2 surface glycoprotein, also known as the spike glycoprotein, is located on the outer envelope of the virion.{53462} It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.{46767,49561} The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.{49542,49536,49558} In this way, ACE2 acts as the functional receptor for SARS-CoV-2. SARS-CoV-2 infection can result in the production of neutralizing antibodies, which bind to the SARS-CoV-2 spike RBD preventing further viral entry and infection, starting approximately 4-10 days after symptom onset.{55337,55338} Cayman’s SARS-CoV-2 Surface Glycoprotein Rabbit Monoclonal Neutralizing Antibody (Clone 004) disrupts the S1-RBD-ACE2 interaction and can be used for ELISA.

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • SARSCoV2 COVID19 corona virus TMPRSS ACE
  • Product Overview:
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.{53462,53459,53461,55257,55258} The SARS-CoV-2 surface glycoprotein, also known as the spike glycoprotein, is located on the outer envelope of the virion.{53462} It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.{46767,49561} The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.{49542,49536,49558} In this way, ACE2 acts as the functional receptor for SARS-CoV-2. SARS-CoV-2 infection can result in the production of neutralizing antibodies, which bind to the SARS-CoV-2 spike RBD preventing further viral entry and infection, starting approximately 4-10 days after symptom onset.{55337,55338} Cayman’s SARS-CoV-2 Surface Glycoprotein Rabbit Monoclonal Neutralizing Antibody (Clone 004) disrupts the S1-RBD-ACE2 interaction and can be used for ELISA.

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