Rufinamide-15N-d2

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Rufinamide-¹⁵N-d₂

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Cat No: 33539

Biochemicals - Ion Channel Modulation

Rufinamide-15N-d2 is intended for use as an internal standard for the quantification of rufinamide (Item No. 18870) by GC- or LC-MS. Rufinamide is an anticonvulsant.{58372} It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when u...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[(2,6-difluorophenyl)methyl-d2]-1H-1,2,3-triazole-4-carboxamide-15N

Correlated keywords:

deuterated deuterium GCMS LCMS CGP33101 CGP 33101 RUF 331 RUF331 anti-convulsant CA-3 Nav Na v 1.1 1.2 1.3 1.6

Product Overview:
Rufinamide-15N-d2 is intended for use as an internal standard for the quantification of rufinamide (Item No. 18870) by GC- or LC-MS. Rufinamide is an anticonvulsant.{58372} It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM.{58370} Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and Nav1.6, opening and increases the action potential threshold in primary rat hippocampal neurons. It is an inhibitor of carbonic anhydrase VA (CAVA; Ki = 343.8 nM) that is selective for CAVA over CAI and CAII (Kis = >10,000 nM for both).{58371} Rufinamide (100 µM) prolongs the preictal phase and reduces seizure-like event frequency in an in vitro model of epileptiform activity in rat hippocampal slices.{58369} It inhibits seizures induced by pentylenetetrazole (Item No. 18682) in a mouse model of epilepsy (ED50 = 54 mg/kg, i.p.) and reduces kainic acid-induced neuronal cell death in the mouse hippocampal CA3 region when used at doses of 25, 50, and 100 mg/kg.{58368,58367} Formulations containing rufinamide have been used in the treatment of seizures associated with Lennox-Gastaut Syndrome (LGS).

Size	1 mg
Shipping	dry ice
CAS Number	1795037-48-7
Molecular Formula	C₁₀H₆D₂F₂N₃[¹⁵N]O
SMILES	FC1=C(C([2H])([2H])N2N=NC(C([15NH2])=O)=C2)C(F)=CC=C1
Molecular Weight	241,2
Formulation	A solid
Purity	≥99% deuterated forms (d1-d2)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.