Deuterated Bile Acids MaxSpec® D

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Deuterated Bile Acids MaxSpec^® Discovery Mixture

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Cat No: 33506

The Deuterated Bile Acids MaxSpec® Discovery Mixture contains deuterated versions of selected bile acids and is ideally suited for use as an internal standard in mass spectrometry applications. Bile acids are formed in the liver primarily from cholest...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

quantitative standard mass Max spec spectrometry lipidomics LC-MS LCMS GPBAR

Product Overview:
The Deuterated Bile Acids MaxSpec® Discovery Mixture contains deuterated versions of selected bile acids and is ideally suited for use as an internal standard in mass spectrometry applications. Bile acids are formed in the liver primarily from cholesterol and then transformed by intestinal microbiota into a diverse array of secondary bile acids.{54792,48224} Primary and secondary bile acids can be modified by conjugation to glycine or taurine via an amide linkage. Bile acids are involved in the degradation of cholesterol in the liver and the solubilization of fatty acids in the small intestine and lipophilic xenobiotics in the biliary tract.{54792} They also bind to and activate bile acid receptors, such as the farnesoid X receptor (FXR) and G protein-coupled bile acid-activated receptor (GP-BAR), which are involved in lipid, glucose, and energy metabolism.{37056} The Deuterated Bile Acids MaxSpec® Discovery Mixture contains deuterated primary and secondary bile acids, as well as glycine- and taurine-conjugated bile acids. Deuterated Bile Acids MaxSpec® Discovery Mixture has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This Deuterated Bile Acids MaxSpec® Discovery Mixture is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Size	1 ea
Shipping	dry ice
Formulation	A mixture in 1 ml methanol (see CofA for concentrations)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.