Capromorelin (tartrate)

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Cat No: 33488

Biochemicals - Receptor Pharmacology

Capromorelin is a growth hormone (GH) secretagogue and an agonist of GH secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.{60360,60361} It stimulates GH release from primary rat pituitary cells with an EC50 value of 3 nM....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-propanamide, (2R,3R)-2,3-dihydroxybutanedioate

Correlated keywords:

193273-66-4 GHS-391 GHS391 AT-002 AT002 CP-424,391 CP424391 RQ00000005 GHSR1a IGF1

Product Overview:
Capromorelin is a growth hormone (GH) secretagogue and an agonist of GH secretagogue receptor 1a (GHS-R1a), which is also known as the ghrelin receptor.{60360,60361} It stimulates GH release from primary rat pituitary cells with an EC50 value of 3 nM.{60360} Capromorelin (0.3, 3, and 30 nM) stimulates intracellular calcium mobilization in primary rat pituitary cells. It increases rat serum GH levels (ED50 = 0.04 mg/kg, i.v.) and decreases dog serum insulin-like growth factor 1 (IGF-1) levels when administered orally at a dose of 1 mg/kg. Capromorelin (3.9 mg/kg, once per day for 28 days) increases rat body weight by 43.6% without affecting whole-body percentages of fat, lean mass, or bone content. It decreases infarct size in a rabbit model of ischemia-reperfusion injury induced by left coronary artery occlusion when administered at a dose of 25 mg/kg.{60362} Formulations containing capromorelin have been used in the treatment of weight loss in cats with chronic kidney disease and as an appetite stimulant in dogs.

Size	1 mg
Shipping	dry ice
CAS Number	193273-69-7
Molecular Formula	C₂₈H₃₅N₅O₄ • C₄H₆O₆
SMILES	OC([C@H](O)[C@@H](O)C(O)=O)=O.CN(C1=O)N=C(CCN(C2)C([C@H](NC(C(C)(N)C)=O)COCC3=CC=CC=C3)=O)[C@]12CC4=CC=CC=C4
Molecular Weight	655,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.