Oxonic Acid-13C2,15N3 (potassium

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Oxonic Acid-¹³C₂,¹⁵N₃ (potassium salt hydrate)

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Cat No: 33282

Biochemicals - Isotopically Labeled Standards

Oxonic acid-13C2,15N3 is intended for use as an internal standard for the quantification of oxonic acid (potassium salt) (Item No. 22586) by GC- or LC-MS. Oxonic acid is a uricase inhibitor (IC50 = 0.8 µM) that prevents metabolism and excretion of uri...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate-4,6-13C2-1,3,5-15N3

Correlated keywords:

deuterated deuterium GCMS LCMS OPRTmediated 5fluorouracil 5FU

Product Overview:
Oxonic acid-13C2,15N3 is intended for use as an internal standard for the quantification of oxonic acid (potassium salt) (Item No. 22586) by GC- or LC-MS. Oxonic acid is a uricase inhibitor (IC50 = 0.8 µM) that prevents metabolism and excretion of uric acid.{58362,40118} It also inhibits orotate phosphoribosyltransferase (ORPT), reducing OPRT-mediated phosphorylation of 5-fluorouracil (5-FU; Item No. 14416) in Yoshida sarcoma cell extracts with an IC50 value of 3.7 µM.{58363} Oxonic acid (10-50 mg/kg) decreases the severity of gastrointestinal tract injury and the incidence of diarrhea induced by the 5-FU prodrug tegafur (Item No. 26076) and uracil (Item No. 26088) without loss of antitumor activity in a rat Yoshida sarcoma model. It has also been used to induce hyperuricemia in rodents.{58364} Formulations containing oxonic acid have been used in the treatment of head, neck, lung, pancreatic, gastric, and breast carcinomas.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₂[¹³C]₂H₂[¹⁵N]₃O₄ • K [XH₂O]
SMILES	O=[13C]([15N]=C(C([O-])=O)[15NH]1)[15NH][13C]1=O.[K+].O
Molecular Weight	200,1
Formulation	A solid
Purity	≥95%
Custom Code	3822.19
UNSPSC code	12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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Oxonic Acid-13C2,15N3 (potassium salt hydrate)