ACU 4429 (hydrochloride)

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Cat No: 33242

Biochemicals - More Biochemicals

ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65; IC50 = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Item No. 33207) in the visual cycle.{58360} It reduces rod photoreceptor recovery in da...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(?R)-?-(2-aminoethyl)-3-(cyclohexylmethoxy)-benzenemethanol, monohydrochloride

Correlated keywords:

1141777-14-1 11trans 11cis darkadapted lightinduced

Product Overview:
ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65; IC50 = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Item No. 33207) in the visual cycle.{58360} It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED50 = 0.21mg/kg) and reversibly decreases the regeneration of 11-cis retinal oxime in the same model (ED50 = 0.18 mg/kg). ACU 4429 also prevents light-induced photoreceptor cell loss in dark-adapted albino mice. It reduces lipofuscin autofluorescence and decreases the level of retinoid toxin (A2E) in the RPE in an Abca4-/- mouse model of Stargardt disease (ED50 = 0.47 mg/kg).

Size	1 mg
Shipping	dry ice
CAS Number	1141934-97-5
Molecular Formula	C₁₆H₂₅NO₂ • HCl
SMILES	NCC[C@H](C1=CC(OCC2CCCCC2)=CC=C1)O.Cl
Molecular Weight	299,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.50
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.