Ganglioside GD2 Polyclonal Antib

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Ganglioside G_D2 Polyclonal Antibody

Cat No: 33235

Ganglioside GD2 (Item No. 25487) is a glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is produced by the transfer of N-acetylgalactosamine (GalNAc; Item No. 31728) from UDP-GalNAc to the precursor ganglio...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Nacetylgalactosamine UDPGalNAc ?1,4 Nacetylgalactosaminyltransferase G D2 M2 M1 A1 D1 epithelialtomesenchymal Antiganglioside GD2positive EL4 IMR32

Product Overview:
Ganglioside GD2 (Item No. 25487) is a glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is produced by the transfer of N-acetylgalactosamine (GalNAc; Item No. 31728) from UDP-GalNAc to the precursor ganglioside GD3(Item No. 17481) by β-1,4-N-acetylgalactosaminyltransferase 1 (β4GalNAcT1), also known as ganglioside GM2/GD2 synthase, and can be galactosylated to ganglioside GD1b (Item No. 19569) by β-1,3-galactosyltransferase 4 (β3GalT4), also known as ganglioside GM1/GA1/GD1 synthase.{58355,58356} Ganglioside GD2 is frequently expressed on the plasma membrane of tumor cells of neuroectodermal origin, including neuroblastomas, as well as bone and soft tissue sarcomas, melanoma, and small cell lung cancer, and is absent or weakly expressed in non-cancerous tissues.{37627,58357} It is induced by expression of the epithelial-to-mesenchymal transition (EMT) inducers Twist and Snail in oncogenic human mammary epithelial cells.{58358} Anti-ganglioside GD2 monoclonal antibodies reduce the viability of GD2-positive EL-4 mouse lymphoma, IMR-32 human neuroblastoma, and mS human melanoma cells, inducing features of both apoptosis and necrosis.{58357} Ganglioside GD2 has been found in more than 90% of neuroblastoma tissue samples, and plasma levels of soluble ganglioside GD2 are associated with tumor progression in patients with neuroblastoma.{58359} Formulations containing chimeric anti-ganglioside GD2 monoclonal antibodies have been used in the treatment of neuroblastoma in children. Ganglioside GD2 Polyclonal Antibody can be used for ELISA and TLC immunoblotting applications. [Matreya, LLC. Catalog No. 1963]

Size	50 µL
Shipping	dry ice
Host	Rabbit
Antigen	Purified ganglioside GD2
Isotype	IgG/IgM
Application(s)	ELISA, TLC immunoblotting
Formulation	A liquid
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.