Asperosaponin VI

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Asperosaponin VI

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Cat No: 33206

Biochemicals - Natural Products

Asperosaponin VI is a triterpenoid saponin that has been found in D. asper and has diverse biological activities.{57507,57506,57508} It increases bone morphogenetic protein 2 (BMP2) levels in, and induces differentiation of, MC3T3-E1 mouse preosteobla...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,4?)-3-(?-L-arabinopyranosyloxy)-23-hydroxy-olean-12-en-28-oic acid, 6-O-?-D-glucopyranosyl-?-D-glucopyranosyl ester

Correlated keywords:

Dendrocalamus bamboo BMP MC3T3E1 MC3T3E E 1

Product Overview:
Asperosaponin VI is a triterpenoid saponin that has been found in D. asper and has diverse biological activities.{57507,57506,57508} It increases bone morphogenetic protein 2 (BMP2) levels in, and induces differentiation of, MC3T3-E1 mouse preosteoblasts in a concentration-dependent manner.{57507} It also inhibits osteoclast formation induced by RANKL in vitro and reduces joint inflammation and bone loss in a mouse model of collagen-induced arthritis when administered at a dose of 20 mg/kg.{57506} Asperosaponin VI (150 and 450 mg/kg) reduces increases in acetic acid-induced vascular permeability and increases the latency to paw withdrawal in the hot plate test in mice.{57508}

Size	10 mg
Shipping	dry ice
CAS Number	39524-08-8
Molecular Formula	C₄₇H₇₆O₁₈
SMILES	OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]2O)O)O)O[C@H]2OC([C@]34[C@](CC(C)(CC4)C)([H])C5=CC[C@@]([C@@]6([C@@]([C@@](C)([C@H](CC6)O[C@H]7[C@@H]([C@H]([C@H](CO7)O)O)O)CO)([H])CC8)C)([H])[C@]8(C)[C@@]5(CC3)C)=O
Molecular Weight	929,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2938.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.