Inostamycin A (sodium salt)

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Cat No: 33018

Biochemicals - Natural Products

Inostamycin A is a bacterial metabolite that has been found in Streptomyces and has anticancer activity.{61331} It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50 = 0.02 µg/ml in A431 cell membranes) and is selective for...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(?R,2R,3S,4R,5S,6R)-?,5-diethyl-6-[(1S,2S,3S,5R)-5-[(2S,2?R,3?R,4S,5S,5?R)-5?-ethyloctahydro-2?-hydroxy-5?-[(1S)-1-hydroxybutyl]-2,3?,4-trimethyl[2,2?-bifuran]-5-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-2,4-dihydroxy-3-methyl-2H-pyran-2-acetic acid, monosodium salt

Correlated keywords:

129905-10-8 anti-cancer YCUT892 KCCTC873 HSC4 YCUT891 MMP2 MMP9

Product Overview:
Inostamycin A is a bacterial metabolite that has been found in Streptomyces and has anticancer activity.{61331} It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50 = 0.02 µg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 µg/ml.{61332} Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a concentration-dependent manner.{61333} It induces cell cycle arrest in the G1 phase in HSC-4 cells when used at a concentration of 250 ng/ml and induces apoptosis in Ms-1 small cell lung cancer cells at 300 ng/ml.{61333,61334} Inostamycin A also reduces levels of matrix metalloproteinase-2 (MMP-2) and MMP-9 and inhibits EGF-induced migration of HSC-4 cells.{61335}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₃₈H₆₈O₁₁ • Na
SMILES	O[C@@]([C@@H](C1)C)([C@@](O[C@]2([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@@H]([C@](O[C@@]3(O)[C@@H](CC)C(O)=O)([H])[C@H]([C@H]([C@@H]3C)O)CC)C)=O)(C[C@@H]2C)C)O[C@@]1(CC)[C@@H](O)CCC.[Na+]
Molecular Weight	723,9
Formulation	A solid
Purity	≥85%
Custom Code	2932.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

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