SB-399885 (hydrochloride)

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Cat No: 32817

Biochemicals - Receptor Pharmacology

SB-399885 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.72 nM).{61175} It is greater than 200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM. SB-399885 inhibits 5-HT-induced c...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide, monohydrochloride

Correlated keywords:

402713-80-8 SB399885 5HT 5HT6 electro shock anti depressant

Product Overview:
SB-399885 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.72 nM).{61175} It is greater than 200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM. SB-399885 inhibits 5-HT-induced cAMP accumulation in HeLa cells expressing recombinant human 5-HT6 receptors (pA2 = 7.85). In vivo, SB-399885 increases the seizure threshold in a rat model of seizures induced by maximal electroshock (MES). It reduces escape latency in the Morris water maze in aged rats and reverses scopolamine-induced impairments in the novel object recognition task in adult rats when administered at a dose of 10 mg/kg. SB-399885 (10 mg/kg) decreases immobility time in the forced swim and tail suspension tests in mice.{61176} It also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.

Size	5 mg
Shipping	dry ice
CAS Number	402713-81-9
Molecular Formula	C₁₈H₂₁Cl₂N₃O₄S • HCl
SMILES	O=S(NC1=C(OC)C(Cl)=CC(Cl)=C1)(C2=CC=C(C(N3CCNCC3)=C2)OC)=O.Cl
Molecular Weight	482,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2935.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.