Thioflavin T

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Thioflavin T

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Cat No: 32553

Thioflavin T is a fluorescent probe for amyloid fibrils.{54673} It displays excitation/emission maxima of 385/445 nm, respectively, and exhibits an increase in fluorescence intensity and a shift in excitation/emission maxima to 450/482 nm upon binding...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

Special Advice: Dangerous Good in said quantity, not available for sale.

Synonyms:

2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazolium, monochloride

Correlated keywords:

20096-11-1 Thioflavine Th-T basic methylene rhoduline yellow 1 N NI acronol lake TC 180 brilliant kansai nankai flavine citroflavine primoflavine purimofurabin tannoflavine 8G 8GO C.I. 49005

Product Overview:
Thioflavin T is a fluorescent probe for amyloid fibrils.{54673} It displays excitation/emission maxima of 385/445 nm, respectively, and exhibits an increase in fluorescence intensity and a shift in excitation/emission maxima to 450/482 nm upon binding to amyloid fibrils.{54673,54675} The fluorescence intensity is also pH dependent, increasing in intensity as the pH increases.{54675} Thioflavin T binds to different types of amyloid fibrils with varying affinity, over two orders of magnitude, depending on type and binding mode.{54674} It has been used with fluorescence microscopy to visualize brain amyloid fibril plaques in a rat model of Alzheimer's disease.{54676}

Size	100 g
Shipping	dry ice
CAS Number	2390-54-7
Molecular Formula	C₁₇H₁₉N₂S • Cl
SMILES	CN(C)C(C=C1)=CC=C1C2=[N+](C)C3=C(C=C(C)C=C3)S2.[Cl-]
Molecular Weight	318,9
Formulation	A crystalline solid
Purity	≥90%
Custom Code	3204.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.