MSH2 Rabbit Monoclonal Antibody

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Cat No: 32300

MutS homolog 2 (MSH2) is a DNA repair protein.{54725} It heterodimerizes with MSH6 or MSH3 to form the MutSα and MutSβ DNA mismatch recognition complexes, respectively, which are divided into five domains: a mismatch-binding domain, connector domain, ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

HNPCC-1 MSH-2 3 6 RM-375

Product Overview:
MutS homolog 2 (MSH2) is a DNA repair protein.{54725} It heterodimerizes with MSH6 or MSH3 to form the MutSα and MutSβ DNA mismatch recognition complexes, respectively, which are divided into five domains: a mismatch-binding domain, connector domain, α-helical lever domain, clamp domain, and an ABC-ATPase domain.{54725,54726} It is ubiquitously expressed and localized to the nucleus.{54725,54726} MSH2, when complexed with MSH6 or MSH3, recognizes DNA polymerase errors in replicated DNA to activate MutL and initiate DNA repair. Missense mutations in MSH2 are associated with hereditary nonpolyposis colorectal cancer (HNPCC).{54725,54727} Polymorphisms in MSH2 are associated with an increased risk of developing prostate cancer.{54728} Cayman’s MSH2 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Recombinant peptide within 500 amino acids of the N-terminus of human MSH2
Clone	RM375
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.