Syntaxin-1A Rabbit Monoclonal An

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Syntaxin-1A Rabbit Monoclonal Antibody

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Cat No: 32292

Syntaxin-1A is a type II integral membrane protein and member of the SNARE complex that has a major role in neuronal exocytosis.{55160,60177} It is composed of a cytoplasmic N-terminal regulatory domain, a coiled-coil SNARE domain that mediates protei...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

HPC1 RM-367 SNAP25 Munc-18

Product Overview:
Syntaxin-1A is a type II integral membrane protein and member of the SNARE complex that has a major role in neuronal exocytosis.{55160,60177} It is composed of a cytoplasmic N-terminal regulatory domain, a coiled-coil SNARE domain that mediates protein-protein interactions, and a C-terminal transmembrane tail that is required for membrane localization.{60170,60171} Syntaxin-1A is located primarily on neuronal plasma membranes and associates with synaptosomal-associated protein 25 (SNAP-25), vesicle-associated membrane protein (VAMP), and the syntaxin-binding protein Munc18 to form the SNARE complex, which facilitates synaptic vesicle docking and neurotransmitter release in a calcium-dependent manner.{55160,60172} It is also found in pancreatic β cells, where it is involved in insulin secretion, as well as in the heart.{60173,60174} STX1A SNPs have been found in patients with Asperger syndrome, attention-deficit hyperactivity disorder (ADHD), or coronary artery disease.{60174,60175,60176} Cayman's Syntaxin-1A Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to residues near the N-terminal of human syntaxin-1A
Clone	RM367
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.