N6-Methyladenosine Rabbit Monocl

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N⁶-Methyladenosine Rabbit Monoclonal Antibody

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Cat No: 32288

N6-Methyladenosine (m6A) is an abundant post-transcriptional RNA modification that is found in various classes of eukaryotic or viral RNA, including mRNA, rRNA, tRNA, snRNA, microRNA (miRNA), and long non-coding RNA (lncRNA).{58224,58223} m6A modifica...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

N6methyladenosine m6 A noncoding 3'UTR METT L3 L14 premRNA YTHdomain

Product Overview:
N6-Methyladenosine (m6A) is an abundant post-transcriptional RNA modification that is found in various classes of eukaryotic or viral RNA, including mRNA, rRNA, tRNA, snRNA, microRNA (miRNA), and long non-coding RNA (lncRNA).{58224,58223} m6A modifications are enriched near stop codons of mRNA transcripts, increasing along the length of the coding region and decreasing after 3’-UTRs.{58224,58225} m6A formation is a reversible process that occurs primarily in the nucleus.{58226} Its formation is catalyzed by a methyltransferase complex that is composed of the writers METTL3 and METTL14, which preferentially methylate RNA substrates with a GGACU domain, and the accessory protein Wilms tumor 1-associating protein (WTAP), which recruits target RNAs.{58224} m6A demethylation is mediated by the erasers fat mass and obesity-associated (FTO) protein and ALKBH5. Upon export into the cytosol, m6A modifications are recognized by a variety of reader proteins, including YTH-domain family (YTHDF) members, which regulate RNA translation. m6A modifications regulate multiple steps of RNA processing, including pre-mRNA splicing, nuclear export, translation, and decay, influencing a variety of critical cellular functions, such as differentiation, neurodevelopment, immunity, and oncogenesis.{58224,58223,58227} Global m6A mRNA levels are decreased in tumor tissue isolated from patients with endometrial cancer.{58228} Cayman’s N6-Methyladenosine Rabbit Monoclonal Antibody can be used for dot blot (DB), ELISA, and methylated RNA immunoprecipitation (MeRIP) applications.

Size	50 µg
Shipping	dry ice
Host	Rabbit
Antigen	BSA-conjugated N6-methyladenosine
Clone	RM362
Isotype	IgG
Application(s)	DB, ELISA, MeRIP
Formulation	50 µg of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.