Stathmin 1 (C-Term) Rabbit Monoc

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Stathmin 1 (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32281

Stathmin 1 is a microtubule-destabilizing phosphoprotein and the founding member of the stathmin family of proteins.{54622,54623} It is composed of a stathmin-like domain (SLD) that contains an N-terminal domain, a proline-rich domain, and two tubulin...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

RM 350 STMN 1 p Op 18 ? ? alpha beta

Product Overview:
Stathmin 1 is a microtubule-destabilizing phosphoprotein and the founding member of the stathmin family of proteins.{54622,54623} It is composed of a stathmin-like domain (SLD) that contains an N-terminal domain, a proline-rich domain, and two tubulin-binding repeats, which each bind one tubulin αβ heterodimer.{54623} Stathmin 1 also contains several phosphorylation sites which, when phosphorylated, negatively regulate its interaction with tubulin. It is ubiquitously expressed, with high levels in the nervous system, and localizes to the cytoplasm. Stathmin 1 binds to tubulin in a phosphorylation-dependent manner and regulates microtubule dynamics by promoting destabilization or preventing polymerization.{54623,54624} Stathmin 1 is inactivated prior to mitosis and reactivated by dephosphorylation near the end of mitosis.{54624} STMN1, the gene encoding stathmin, is overexpressed in a variety of cancers and is associated with metastasis and poor prognosis.{54622,54625} Cayman’s Stathmin (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human stathmin 1
Clone	RM350
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.