GST3/GST-Pi (C-Term) Rabbit Mono

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GST3/GST-Pi (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32279

Glutathione S-transferase 3 (GST3), also known as GST-Pi, is an enzyme that catalyzes the conjugation of glutathione (GSH) to the electrophilic center of various phase I toxic xenobiotic metabolites, facilitating their excretion by phase III membrane ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Stransferase GSTPi Nterminal GSHbinding Cterminal Hsite Snitrosoglutathione GSTP 1 Cterm

Product Overview:
Glutathione S-transferase 3 (GST3), also known as GST-Pi, is an enzyme that catalyzes the conjugation of glutathione (GSH) to the electrophilic center of various phase I toxic xenobiotic metabolites, facilitating their excretion by phase III membrane channels, transporters, and pumps.{58213} It functions as a homodimer, with each monomer containing an N-terminal GSH-binding domain and a C-terminal domain with a hydrophobic cavity (H-site) for toxic compound binding. GST3 is expressed primarily in erythrocytes, as well as in the brain, heart, lung, testis, skin, kidney, pancreas, and saliva. GST3 dimers can bind a nitric oxide (NO) carrier, such as S-nitrosoglutathione or dinitrosyl-diglutathionyl-iron complex (DNDGIC), with one active site, indicating a role in the storage and transport of NO, while maintaining detoxification activity in the second active site.{58214} Expression of GSTP1, the gene encoding GST3, is increased in patients with advanced-stage chronic kidney disease. GSTP1 polymorphisms are associated with increased risk of Parkinson's disease following exposure to cigarette smoke or pesticides, as well as with amyotrophic lateral sclerosis. Cayman's GST3/GST-Pi (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µL
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human GST3
Clone	RM347
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.