PSA Rabbit Monoclonal Antibody

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Cat No: 32273

Prostate-specific antigen (PSA) is an androgen-regulated serine protease and member of the tissue kallikrein family that is encoded by KLK3 in humans.{54580} It is synthesized with a leader sequence, which is cleaved to generate the enzymatically inac...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

RM 323 KLK 3 pro-PSA

Product Overview:
Prostate-specific antigen (PSA) is an androgen-regulated serine protease and member of the tissue kallikrein family that is encoded by KLK3 in humans.{54580} It is synthesized with a leader sequence, which is cleaved to generate the enzymatically inactive precursor protein proPSA, which is then cleaved between arginine and isoleucine at positions 7 and 8, respectively, to generate enzymatically active PSA. PSA is expressed primarily by the secretory epithelial cells in the acini and ducts of the prostate gland and is the major protein in seminal fluid where it cleaves enogelin I and II, proteins that mediate gel formation in semen. It is expressed at lower levels in the paraurethral and perianal glands, breast, thyroid, and placental tissues, and apocrine sweat glands. In prostate cancer, the prostate epithelial basement membrane is disrupted which allows PSA to enter the peripheral circulation where it is bound by the protease inhibitor alpha-1-antichymotrypsin (ACT). Serum levels of PSA are commonly used for preventative prostate cancer screening.{54580,54581} Cayman's PSA Rabbit Monoclonal Antibody can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB; non-reducing conditions) applications. The antibody recognizes free PSA and PSA complexed with ACT (PSA-ACT) from human samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Native human PSA purified from seminal fluid
Clone	RM323
Isotype	IgG
Application(s)	ELISA, IHC, WB (non-reducing conditions)
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.