Cytokeratin 14 (C-Term) Rabbit M

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Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32266

Cytokeratin 14 (CK-14) is a type I acidic epithelial intermediate filament protein.{59574} It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

31121500 cyto keratin CK-14 immuno chemical nonhelical keratino cytes skeleton plasm histochemistry histo chemistry cytokeratin14 cytoskeletal14 keratin14 KRT-14

Product Overview:
Cytokeratin 14 (CK-14) is a type I acidic epithelial intermediate filament protein.{59574} It is composed of a central rod containing four α-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.{59575,59576} CK-14 is expressed in stratified squamous epithelial cells, keratinocytes, and myoepithelial cells in the basal layer of the epidermis and is an integral component of the epithelial cell cytoskeleton.{59574,59577,59578} It dimerizes with the type II basic epithelial intermediate filament protein CK-5 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.{59575,59576} Increased tumor levels of CK-14 have been found in patients with squamous cell carcinomas of the bladder, lung, or cervix.{59579} Mutations in the gene encoding CK-14 have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering.{58059} Cayman's Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human cytokeratin 14
Clone	RM328
Isotype	IgG
Application(s)	IHC and WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.