PD-1/CD279 (N-Term) Rabbit Monoc

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PD-1/CD279 (N-Term) Rabbit Monoclonal Antibody

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Cat No: 32253

Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor belonging to the immunoglobulin superfamily that is involved in regulation and attenuation of the adaptive immune response.{52533,53686} It is a 288-amino acid typ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

PD1 CD 279 288amino 167amino Nloop IgVlike CD4 + Tcell CD8 + PDL1 PDL2 lupuslike BALBc Nterm

Product Overview:
Programmed cell death protein 1 (PD-1), also known as CD279, is a cell surface receptor belonging to the immunoglobulin superfamily that is involved in regulation and attenuation of the adaptive immune response.{52533,53686} It is a 288-amino acid type I transmembrane protein encoded by the PDCD1 gene in humans and is comprised of a 167-amino acid ectodomain consisting of an N-loop, IgV-like domain, and a stalk region, a transmembrane domain, and a cytoplasmic tail with two tyrosine-based signaling motifs.{53687,53689,53686,52533} PD-1 is expressed in activated immune cells including CD4+ T cells, CD8+ T cells, natural killer T (NKT) cells, B cells, monocytes, and dendritic cells.{53690,53686} Binding of PD-1 to either of its ligands, PD-L1 (Item No. 28378) or PD-L2 (Item No. 28379), suppresses T cell proliferation and cytokine production.{52533} PD-1 deficiency induces cardiomyopathy or lupus-like glomerulonephritis in BALB/c and C57Bl/6 mice, respectively.{53687,53686} Increased levels of intratumoral PD-1+ immune cells are associated with increased tumor size, higher nuclear grade, and poor prognosis in patients with renal cell carcinoma.{53688} Formulations containing PD-1 blocking antibodies have been used in the treatment of various cancers. Cayman’s PD-1/CD279 (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the N-terminal region of human PD-1
Clone	RM309
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody.
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.