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- eIF2? (Phospho-Ser51) Rabbit Monoclonal Antibody
eIF2? (Phospho-Ser51) Rabbit Monoclonal Antibody
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Cat No: 32244
eIF2α is the α subunit of eukaryotic inhibition factor 2, which also includes eIF2β and eIF2γ subunits and is involved in the initiation of translation.{59683} eIF2α is composed of a globular N-terminal domain, which contains an S1 domain and an α-hel...
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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
- eIF 2? Ser 51 phosphoSer51 2? ?helical EIF 2AK1 EIF2AK 1 2B ATF 4 PP GADD
Product Overview:
eIF2α is the α subunit of eukaryotic inhibition factor 2, which also includes eIF2β and eIF2γ subunits and is involved in the initiation of translation.{59683} eIF2α is composed of a globular N-terminal domain, which contains an S1 domain and an α-helical domain, and a globular C-terminal domain.{59684} eIF2α can be phosphorylated at serine 51 by the eIF2α kinases HRI/EIF2AK1, PKR/EIF2AK2, PERK/EIF2AK3, and GCN2/EIF2AK4 following various cell and ER stressors, viral invasion, or nutrient deprivation, among other factors.{59685,59686,59687} Phosphorylation of eIF2α at serine 51 promotes the interaction between eIF2α and the guanine nucleotide exchange factor eIF2B, which inhibits eIF2B activity and prevents the initiation of translation, reducing global protein synthesis in the cell.{59683} The transcription of specific factors involved in the integrated stress response (ISR), such as ATF4, is upregulated by eIF2α phosphorylation.{59685} Dephosphorylation of eIF2α by the protein phosphatase 1 (PP1) complex, which includes GADD34 and CReP, terminates the ISR and returns protein synthesis back to basal levels. Cayman’s eIF2α (Phospho-Ser51) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
eIF2α is the α subunit of eukaryotic inhibition factor 2, which also includes eIF2β and eIF2γ subunits and is involved in the initiation of translation.{59683} eIF2α is composed of a globular N-terminal domain, which contains an S1 domain and an α-helical domain, and a globular C-terminal domain.{59684} eIF2α can be phosphorylated at serine 51 by the eIF2α kinases HRI/EIF2AK1, PKR/EIF2AK2, PERK/EIF2AK3, and GCN2/EIF2AK4 following various cell and ER stressors, viral invasion, or nutrient deprivation, among other factors.{59685,59686,59687} Phosphorylation of eIF2α at serine 51 promotes the interaction between eIF2α and the guanine nucleotide exchange factor eIF2B, which inhibits eIF2B activity and prevents the initiation of translation, reducing global protein synthesis in the cell.{59683} The transcription of specific factors involved in the integrated stress response (ISR), such as ATF4, is upregulated by eIF2α phosphorylation.{59685} Dephosphorylation of eIF2α by the protein phosphatase 1 (PP1) complex, which includes GADD34 and CReP, terminates the ISR and returns protein synthesis back to basal levels. Cayman’s eIF2α (Phospho-Ser51) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
| Size | 100 µl |
| Shipping | dry ice |
| Host | Rabbit |
| Antigen | Phosphopeptide corresponding to human eIF2? (phospho-Ser51) |
| Clone | RM298 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom Code | 3822.19 |
| UNSPSC code | 12352203 |
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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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