CD20 (C-Term) Rabbit Monoclonal Antibody

CD20 (C-Term) Rabbit Monoclonal Antibody

CAT N°: 32222
Price:

€642.00 €545.70

CD20 is a non-glycosylated protein encoded by MS4A1 in humans.{59585} It is comprised of four transmembrane domains, a single intracellular loop, and two extracellular loop domains with both the N- and C-termini located in the cytosol. CD20 is a general B cell marker that is expressed from the late pre-B lymphocyte stage but is not expressed by pro-B lymphocytes and is lost in terminally differentiated plasma cells and plasmablasts. It forms supramolecular complexes with CD53, CD81, and CD82, as well as MHCII, CD40, B cell receptors, and C-terminal Src kinase-binding protein (CBP) to contribute to signal transduction. MS4A1 expression is variable in B cell malignancies, with the lowest expression found in patients with chronic lymphocytic leukemia (CLL) and the highest expression found in patients with diffuse large B cell lymphoma (DLBCL) or hairy cell lymphomas. MS4A1 expression is enriched on IFN-?-inducible T-box transcription factor-expressing B cells in blood isolated from patients with multiple sclerosis.{59586} Cayman’s CD20 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • CD-20 53 81 82 40 MS4A-1 MS4-A1 MS-4A1 IFN? RM-272
  • Product Overview:
    CD20 is a non-glycosylated protein encoded by MS4A1 in humans.{59585} It is comprised of four transmembrane domains, a single intracellular loop, and two extracellular loop domains with both the N- and C-termini located in the cytosol. CD20 is a general B cell marker that is expressed from the late pre-B lymphocyte stage but is not expressed by pro-B lymphocytes and is lost in terminally differentiated plasma cells and plasmablasts. It forms supramolecular complexes with CD53, CD81, and CD82, as well as MHCII, CD40, B cell receptors, and C-terminal Src kinase-binding protein (CBP) to contribute to signal transduction. MS4A1 expression is variable in B cell malignancies, with the lowest expression found in patients with chronic lymphocytic leukemia (CLL) and the highest expression found in patients with diffuse large B cell lymphoma (DLBCL) or hairy cell lymphomas. MS4A1 expression is enriched on IFN-?-inducible T-box transcription factor-expressing B cells in blood isolated from patients with multiple sclerosis.{59586} Cayman’s CD20 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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