N-Cadherin Monoclonal Antibody

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Cat No: 32208

N-cadherin is an adhesion molecule that mediates the formation of adherens junctions and regulates tissue formation and neural development.{58064,58065} It is a transmembrane glycoprotein that contains an extracellular cadherin domain that forms cell-...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Ncadherin ?catenin epithelialmesenchymal ERKMAPK

Product Overview:
N-cadherin is an adhesion molecule that mediates the formation of adherens junctions and regulates tissue formation and neural development.{58064,58065} It is a transmembrane glycoprotein that contains an extracellular cadherin domain that forms cell-cell interactions, a transmembrane domain, and a cytoplasmic domain that interacts with a variety of adaptor proteins, including β-catenin, to influence cytoskeletal dynamics.{58064} N-cadherin is widely expressed in the nervous system, as well as in osteoblasts, endothelial cells, and stromal cells, and localizes to the cell surface where it forms adherens junctions that stabilize FGFR, activating ERK/MAPK signaling and promoting cell survival and migration.{58065} N-cadherin cell surface expression is regulated by endocytosis and is required for neuronal patterning and regulation of FGFR activity.{58066} Upregulation of N-cadherin is a key feature of the epithelial-mesenchymal transition (EMT), a process that promotes tumorigenesis and cancer metastasis.{58064} Tumor N-cadherin levels are increased in patients with a variety of epithelial or non-epithelial solid cancers, including lung, breast, or skin, and are associated with decreased overall survival.{58067} Cayman’s N-Cadherin Rabbit Monoclonal Antibody can be used for Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to human N-cadherin
Clone	RM259
Isotype	IgG
Application(s)	WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.