Caspase-3 Rabbit Monoclonal Anti

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Caspase-3 Rabbit Monoclonal Antibody (Clone RM250)

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Cat No: 32203

Caspase-3 is a cysteinyl aspartic protease with roles in both extrinsic and intrinsic apoptosis.{31875,8444} Upon apoptotic signaling via death receptors or mitochondrial assembly of pro-apoptotic factors, the zymogen procaspase-3 is cleaved into two ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

proapoptotic p 12 17 ADPribose DNAPK GAS 2

Product Overview:
Caspase-3 is a cysteinyl aspartic protease with roles in both extrinsic and intrinsic apoptosis.{31875,8444} Upon apoptotic signaling via death receptors or mitochondrial assembly of pro-apoptotic factors, the zymogen procaspase-3 is cleaved into two subunits, p17 and p12, which form an active heterodimer that recognizes and cleaves proteins containing the canonical peptide sequence DEVD to drive apoptosis.{57319,57320} Substrates for caspase-3 include the death substrate poly(ADP-ribose) polymerase (PARP), DNA-PK, actin, GAS2, and procaspase-6.{18385,6292} The percentage of caspase-3-positive neurons is positively correlated with dopaminergic neuronal loss in the substantia nigra pars compacta of postmortem brains from patients with Parkinson’s disease, as well as several animal models of chronic neurodegenerative disorders.{57321} Cardiac levels of caspase-3 are increased in patients with ventricular arrhythmia, and activated caspase-3 is found in myocardium isolated from patients with end-stage heart failure.{57322} Cayman’s Caspase-3 Rabbit Monoclonal Antibody (Clone RM250) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes the p17 subunit to detect caspase-3 in human samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide corresponding to human caspase-3 subunit p17
Clone	RM250
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.