p38? MAPK Rabbit Monoclonal Anti

Confirm delete?

p38? MAPK Rabbit Monoclonal Antibody (Clone RM245)

Zoom

Cat No: 32199

p38 MAPK is a serine/threonine protein kinase and member of the MAPK family with roles in the regulation of immune responses and embryonic development, as well as cell differentiation, metabolism, and survival.{60066,60067} It exists as 4 isoforms, p3...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

p-38 ? 38? MAPK-14 11 12 13 2K BACE PS RM-245

Product Overview:
p38 MAPK is a serine/threonine protein kinase and member of the MAPK family with roles in the regulation of immune responses and embryonic development, as well as cell differentiation, metabolism, and survival.{60066,60067} It exists as 4 isoforms, p38α, -β, -γ, and -δ, encoded by MAPK14, MAPK11, MAPK12, and MAPK13, respectively, in humans. p38α MAPK is ubiquitously expressed, with the highest levels of expression in heart, skeletal muscle, and brain.{60066,60068} It is activated via dual phosphorylation of threonine 180 and tyrosine 182 by the MAP2K kinases MKK3 and MKK6 in response to LPS or the production of inflammatory cytokines.{60066,60067} Downstream signaling targets of p38α MAPK include protein kinases, transcription factors, and transcriptional regulators, among others.{60067} Knockdown of Mapk14 is embryonic lethal, while macrophage-specific deletion of Mapk14 inhibits inflammatory cytokine production and is protective against cecal ligation and puncture-induced sepsis in mice.{60067,60068} Mapk14 knockdown also increases lysosomal degradation of β-secretase 1 (BACE1) and decreases amyloid-β (Aβ) production in the APP/PS1 double transgenic mouse model of Alzheimer's disease.{60069} Cayman's p38α MAPK Monoclonal Antibody (Clone RM245) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes p38α MAPK at approximately 38 kDa from human samples.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to p38? MAPK (aa 300-360)
Clone	RM245
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.