4-1BB Ligand Extracellular Domai

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4-1BB Ligand Extracellular Domain (human, recombinant)

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Cat No: 32067

Proteins - More Proteins

TNF ligand superfamily member 9 (4-1BB ligand) is a type II transmembrane glycoprotein and a member of the TNF superfamily.{54191,54192} It is composed of an N-terminal cytoplasmic region, a transmembrane domain, and a C-terminal extracellular tail re...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CD 40 137 8 L TNFSF 9 IgG 1 NF?B PI3KAkt extra cellular 41BB glyco protein

Product Overview:
TNF ligand superfamily member 9 (4-1BB ligand) is a type II transmembrane glycoprotein and a member of the TNF superfamily.{54191,54192} It is composed of an N-terminal cytoplasmic region, a transmembrane domain, and a C-terminal extracellular tail region that contains a TNF homology domain.{54192,54193} 4-1BB ligand production is induced in antigen-presenting cells (APCs), such as dendritic cells, B cells, and macrophages, by CD40 and toll-like receptor (TLR) activation.{54192} It forms homotrimers and binds to its receptor, 4-1BB, on antigen-primed T cells, which induces NF-κB and MAPK signaling through TNF receptor-associated factors (TRAFs) and, when the T cell is co-stimulated by other factors, induces PI3K-Akt signaling.{54191,54192} This action promotes the proliferation of T cells, production of cytokines, and cell survival.{54192} Soluble forms of 4-1BB ligand, consisting of only the extracellular domain, also form trimers that bind to its receptor but do not induce signaling.{54194} Mice deficient for 4-1BB ligand, Tnfsf9, have impairments in the formation of CD8+ T cell memory cells and in clearing pathogens.{54192,54197} Tnfsf9 knockout mice also develop B cell lymphomas before 12 months of age.{54195} 4-1BB ligand antibodies induce T regulatory cell expansion and prevent allogeneic graft rejection of pancreatic islets in mice.{54196} Intratumoral adenovirus-mediated gene transfer of Tnfsf9 induces tumor regression in a mouse syngeneic model of breast cancer.{54195} The protein levels of 4-1BB ligand are elevated in more than 40% of patients with acute myeloid leukemia (AML) or non-Hodgkin’s lymphoma but the expression of TNFSF9 is either elevated or reduced in cancer patients depending on the type of cancer. Cayman’s 4-1BB Ligand Extracellular Domain (human, recombinant) protein can be used for ELISA and binding assay applications. This protein is a disulfide-linked homodimer. The reduced monomer, comprised of 4-1BB ligand (amino acids 71-254) fused to human IgG1 Fc at the N-terminus, consists of 444 amino acids and has a calculated molecular weight of 47.9 kDa.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.4
Purity	≥85% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.