CCL20 (human, recombinant)

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Cat No: 32053

Proteins - More Proteins

Chemokine (C-C motif) ligand 20 (CCL20) is a cytokine of the C-C motif chemokine family.{53762} CCL20 is a monomer comprised of an N-terminal region, a DCCL motif linked to the first β strand of a three-stranded antiparallel β sheet that forms a loop ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CC Chemokine LARC CCL-20 MIP-3? MIP3? A-20 Escherichia CCR-6 hepato-cellular CKb4 CK-b4 Exodus SCY-A20 ST38 ST-38

Product Overview:
Chemokine (C-C motif) ligand 20 (CCL20) is a cytokine of the C-C motif chemokine family.{53762} CCL20 is a monomer comprised of an N-terminal region, a DCCL motif linked to the first β strand of a three-stranded antiparallel β sheet that forms a loop region, and a C-terminal α helix. The flexible N-terminal and loop regions are important for receptor binding. It is produced as a 96-amino acid precursor protein from which mature CCL20 is formed by proteolytic cleavage of a signal sequence. CCL20 is constitutively expressed primarily in the liver, lung, appendix, and tonsils, as well as in macrophages, dendritic cells, leukocytes, colonic epithelial cells, and keratinocytes. Its expression is induced in response to cytokines, bacteria, and viruses in epithelial cells of the tonsils and lower airway, a variety of immune cells, melanocytes, and dermal fibroblasts. It binds to chemokine (C-C motif) receptor 6 (CCR6) on leukocytes in a cell subtype-, maturation stage-, or differentiation stage-dependent manner and attracts immature dendritic cells or memory T or B cells. CCL20 is overexpressed in a variety of cancer cells and attracts immature dendritic cells to the tumor microenvironment.{53763} Overexpression of CCL20 in triple-negative breast cancer (TNBC) cells increases proliferation in vitro and increases the tumor growth rate in mouse xenograft models. Its expression is increased in tumor tissue from patients with hepatocellular carcinoma, and the expression level is positively associated with a lower survival rate. CCL20 expression and protein levels are increased in a variety of other diseases, including in skin lesions of patients with atopic dermatitis or psoriasis and in inflamed-joint synovial fluid from patients with rheumatoid arthritis.{53762} Cayman’s CCL20 (human, recombinant) protein consists of 87 amino acids and has a calculated molecular weight of 10.2 kDa.

Size	50 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.4
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.