SOD2/Mn-SOD (human, recombinant)

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Cat No: 32029

Proteins - More Proteins

Superoxide dismutase 2 (SOD2)/manganese SOD (Mn-SOD) is an antioxidant enzyme that protects cells from oxidative stress by scavenging superoxide anions.{55250} It exists as a homotetramer where each monomer is composed of an N-terminal α-hairpin domai...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

IPOB MNSOD MVCD6 Super-oxide anti-oxidant Sod 2 over-expression CA 1 SDSPAGE ?hairpin Escherichia

Product Overview:
Superoxide dismutase 2 (SOD2)/manganese SOD (Mn-SOD) is an antioxidant enzyme that protects cells from oxidative stress by scavenging superoxide anions.{55250} It exists as a homotetramer where each monomer is composed of an N-terminal α-hairpin domain and a C-terminal α/β domain that contain Mn-binding catalytic active sites.{55250,55251} SOD2 is expressed in the mitochondria and is localized to the mitochondrial matrix where it catalyzes the dismutation of superoxide to hydrogen peroxide and oxygen by alternating reduction and reoxidation of Mn at the enzyme active site.{55250} Genetic deletion of Sod2 in mice induces metabolic acidosis and lipid accumulation in the liver and skeletal muscle, and is perinatal lethal.{46984} Transgenic SOD2 overexpression reduces superoxide levels in the hippocampal CA1 region and extends the lifespan of aged mice.{46985} SOD2 expression is reduced in tumors from patients with hepatocellular carcinoma (HCC) and this decrease is associated with increased tumor number, metastasis, and reduced survival.{46986} SOD2 SNPs have been found in patients with non-Hodgkin's lymphoma, lung cancer, or colorectal cancer.{46987} Cayman's SOD2/Mn-SOD (human, recombinant) protein consists of 199 amino acids and has a calculated molecular weight of 22.3 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 25 kDa.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.5
Purity	≥97% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.