DS-TNFR2 M196R variant (human, r

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DS-TNFR2 M196R variant (human, recombinant)

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Cat No: 32023

Proteins - More Proteins

TNF receptor 2 (TNFR2), also known as CD120b or TNFRSF1B, is a TNF-α receptor encoded by TNFRSF1B and expressed in cells of hematopoietic origin, as well as endothelial cells.{56067,56068,56069} Alternative splicing leads to the formation of a soluble...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

TNFR 2 CD 120b TNFRSF 1B TNF? DSTNFR2 RA M196 R M 196R 196 Leu 23 SDSPAGE TNF-R2 p75 p 75 80 p80 p75TNFR TBPII TNF-R-II TNF-R75 TNFBR TNFR1B TNFR80

Product Overview:
TNF receptor 2 (TNFR2), also known as CD120b or TNFRSF1B, is a TNF-α receptor encoded by TNFRSF1B and expressed in cells of hematopoietic origin, as well as endothelial cells.{56067,56068,56069} Alternative splicing leads to the formation of a soluble, secreted isoform of TNFR2, known as differential splicing TNFR2 (DS-TNFR2), lacking the transmembrane and cytoplasmic domains.{56067} Cell supernatants containing DS-TNFR2 inhibit TNF-α-induced cytotoxicity in L929 cells. Serum levels of DS-TNFR2 are elevated in patients with rheumatoid arthritis. Single nucleotide polymorphisms in TNFRSF1B resulting in a methionine-to-arginine substitution at position 196 (M196R) are associated with susceptibility to systemic lupus erythematosus (SLE) in Japanese patients, rheumatoid arthritis risk in European patients, and polycystic ovary syndrome (PCOS) in female patients.{56070,56069,56068} Cayman's DS-TNFR2 M196R variant (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 257 amino acids, has a calculated molecular weight of 27.7 kDa, and a predicted N-terminus of Leu23 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 43 kDa due to glycosylation.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.4
Purity	≥95% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.