GITR Extracellular Domain (human

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GITR Extracellular Domain (human, recombinant)

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Cat No: 32017

Proteins - More Proteins

Glucocorticoid-induced TNFR-related protein (GITR), also known as TNF receptor superfamily member 18 (TNFRS18), is a type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily with roles in acquired and innate immun...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

FNFRS 18 TNF R NF?B nonlymphoid Toxoplasma antiGITR proinflammatory CD 4 25 high 127 low GL 261 SDSPAGE posttranslational PTM AITR CD 357 GITRD Activation-inducible

Product Overview:
Glucocorticoid-induced TNFR-related protein (GITR), also known as TNF receptor superfamily member 18 (TNFRS18), is a type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily with roles in acquired and innate immunity.{56065} It is composed of an extracellular domain that contains a ligand binding site, a transmembrane domain, and a cytoplasmic domain that facilitates the induction of NF-κB signaling.{56065,56063} GITR is primarily expressed in immature and mature T cells and natural killer (NK) cells but is also expressed at low levels in mast cells, eosinophils, B cells, macrophages, as well as non-lymphoid tissues, osteoclast precursor cells, keratinocytes, and retinal epithelial cells. Upon binding of its ligand GITRL (Item No. 32018), GITR binds various TNF receptor-associated factors (TRAFs) and induces signaling in a cell type-specific manner.{56061} GITR protein levels are increased in macrophages and dendritic cells in a mouse model of T. gondii infection, and administration of an agonistic anti-GITR antibody increases pro-inflammatory cytokine production in peritoneal fluid and reduces chronic phase parasite burden in the same model.{56062} Protein levels of GITR are also increased on CD4+CD25+, CD4+CD25high, and CD4+CD25+CD127low/- regulatory T cells isolated from patients with systemic lupus erythematosus (SLE) compared with healthy controls.{56066} Intratumor, but not peripheral, administration of an agonistic anti-GITR antibody increases overall survival in a GL261 murine glioma model.{56064} Cayman's GITR Extracellular Domain (human, recombinant) protein can be used for ELISA. This protein consists of 147 amino acids, has a calculated molecular weight of 16 kDa, and a predicted N-terminus of Gln26 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the molecular mass of the protein is approximately 27 kDa due to apparent post-translational modifications.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.4
Purity	≥95% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352202

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.