Prochlorperazine-d8 (hydrochlori

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Prochlorperazine-d₈ (hydrochloride)

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Cat No: 31916

Biochemicals - Isotopically Labeled Standards

Prochlorperazine-d8 is intended for use as an internal standard for the quantification of prochlorperazine (Item No. 20742) by GC- or LC-MS. Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-chloro-10-[3-(4-methyl-1-piperazinyl-d8)propyl]-10H-phenothiazine, dihydrochloride

Correlated keywords:

1215641-01-2 deuterated deuterium GCMS LCMS 5HT N1E115 neuro blastoma oligo nucleotides anti emetics

Product Overview:
Prochlorperazine-d8 is intended for use as an internal standard for the quantification of prochlorperazine (Item No. 20742) by GC- or LC-MS. Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₂₀H₁₆ClD₈N₃S • 2HCl
SMILES	CN1C([2H])([2H])C([2H])([2H])N(CCCN2C(C=CC=C3)=C3SC4=C2C=C(Cl)C=C4)C([2H])([2H])C1([2H])[2H].Cl.Cl
Molecular Weight	454,9
Formulation	A solid
Purity	≥98%
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

Prochlorperazine-d8 (hydrochloride)