PVR/CD155 Extracellular Domain (

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PVR/CD155 Extracellular Domain (human, recombinant)

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Cat No: 31826

Proteins - More Proteins

Poliovirus receptor (PVR), also known as CD155, is a member of the nectin-like family of adhesion molecules encoded by the PVR gene in humans that regulates cell migration and proliferation and immune cell activation.{53805} It contains an N-terminal ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

HEK-293 CD-155 226 C-1 2 ?V-?3 ?V?-3 DNAM1 CD-96 B-16 F-10 Trp-21 IgG-1 Necl5 TAGE-4

Product Overview:
Poliovirus receptor (PVR), also known as CD155, is a member of the nectin-like family of adhesion molecules encoded by the PVR gene in humans that regulates cell migration and proliferation and immune cell activation.{53805} It contains an N-terminal extracellular domain with three immunoglobulin-like (Ig-like) loops, C1-like and C2 domains that mediate dimerization, a transmembrane segment that acts as a ligand for receptors expressed by immune cells, and a C-terminal cytoplasmic tail that interacts with intracellular scaffold proteins.{53805,53806} PVR is highly expressed by enterocytes and gastrointestinal lymphatic tissues.{53807} It localizes to the cell surface where it forms cis-homodimers that associate by trans-interactions with nectin-3 cis-homodimers expressed on adjacent cells, resulting in cell-cell adhesion.{53805} PVR internalization by endocytosis disrupts PDGFR and integrin αVβ3 signaling, inducing contact inhibition of cell movement and proliferation.{53805,53806} PVR binds the co-stimulatory receptor CD226/DNAM-1 (Item Nos. 32071
32072), which is widely expressed by most immune cells, including T cells, B cells, natural killer (NK) cells, and monocytes, and the inhibitory receptors TIGIT (Item No. 32081) and CD96, which are expressed by NK cells and T cells, inducing activation or inhibition of immune cells in a receptor-specific manner.{53805} It is also the receptor for poliovirus attachment and entry into cells. In cancer cells, PVR expression is upregulated by FGF stimulation or expression of the oncogene Ras and downregulated by the unfolded protein response.{53808} Pvr knockdown reduces tumor growth and the number of lung metastases in B16/F10 or LWT1 mouse melanoma models.{53809} Cayman's PVR/CD155 Extracellular Domain (human, recombinant) protein can be used for binding assay applications. This protein is a disulfide-linked homodimer. The reduced monomer, comprised of PVR (amino acids 21-345) fused to human IgG1 Fc at its C-terminus, consists of 561 amino acids, has a calculated molecular weight of 61.8 kDa, and a predicted N-terminus of Trp21 after signal peptide cleavage. As a result of glycosylation, the monomer migrates at approximately 95 to 105 kDa by SDS-PAGE under reducing conditions.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.4
Purity	≥95% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.