Nisoldipine-d6

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Nisoldipine-d₆

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Cat No: 31785

Biochemicals - Ion Channel Modulation

Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine (Item No. 20998) by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (K...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-methyl 5-(2-(methyl-d3)propyl-3,3,3-d3) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Correlated keywords:

deuterated deuterium BAY-K-5552 BAYK-5552 BAYK5552

Product Overview:
Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine (Item No. 20998) by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{33001,59310} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.

Size	500 µg
Shipping	dry ice
CAS Number	1285910-03-3
Molecular Formula	C₂₀H₁₈D₆N₂O₆
SMILES	CC(NC(C)=C1C(OCC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2
Molecular Weight	394,5
Formulation	A solid
Purity	≥99% deuterated forms (d1-d6)
Custom Code	3822.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.