Taurolithocholic Acid-d4 MaxSpec

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Taurolithocholic Acid-d₄ MaxSpec^® Standard

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Cat No: 31571

Biochemicals - Analytical Standards

Taurolithocholic acid-d4 (TLCA-d4) is intended for use as an internal standard for the quantification of TLCA (Item No. 17275) by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid (Item No. 20253).{33902} TLCA...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[[(3?,5?)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid

Correlated keywords:

deuterated deuterium GCMS LCMS quantitative standard mass Max spec spectrometry lipidomics LC-MS NSC681057 NSC 681057 CASP3 CASP7 CASP Hep 3B Hep3 B non-transfected

Product Overview:
Taurolithocholic acid-d4 (TLCA-d4) is intended for use as an internal standard for the quantification of TLCA (Item No. 17275) by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid (Item No. 20253).{33902} TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.{28235} It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.{28234,43818} Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.{33902} TLCA-d4 MaxSpec® standard is a quantitative grade standard of TLCA-d4 (Item No. 32984) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This TLCA-d4 MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Size	100 µg
Shipping	dry ice
CAS Number	2410279-96-6
Molecular Formula	C₂₆H₄₁D₄NO₅S
SMILES	O=C(NCCS(O)(=O)=O)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Weight	487,7
Formulation	A solution in methanol at 100 µg/ml (nominal); see CofA for verified concentration
Purity	≥95%
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

Taurolithocholic Acid-d4 MaxSpec® Standard