Calcitonin (eel)

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Calcitonin (eel)

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Cat No: 31487

Biochemicals - Peptides

Calcitonin is a 32-amino acid peptide hormone that lowers blood calcium levels and inhibits bone resorption.{38632,39431} The amino acid sequence of eel calcitonin varies from salmon (Item No. 24410) and human (Item No. 24409) calcitonin at 3 and 16 p...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

26-L-aspartic acid-27-L-valine-29-L-alanine-calcitonin (salmon)

Correlated keywords:

AA CTR

Product Overview:
Calcitonin is a 32-amino acid peptide hormone that lowers blood calcium levels and inhibits bone resorption.{38632,39431} The amino acid sequence of eel calcitonin varies from salmon (Item No. 24410) and human (Item No. 24409) calcitonin at 3 and 16 positions, respectively.{57212} Calcitonin (eel) binds to calcitonin receptor 2 (CTR2) with higher affinity than human, porcine, or rat calcitonin (Kis = 0.01, 2.95, 0.44, and 5.89 nM, respectively, in radioligand binding assays). It inhibits gastric emptying in conscious dogs more potently than human calcitonin when administered at a dose of 10 µg/kg.{57212,57213} Calcitonin (eel) increases the paw withdrawal threshold in a mouse model of carrageenan-induced inflammation when administered at a dose of 0.2 µg/paw.{57214}

Size	1 mg
Shipping	dry ice
CAS Number	57014-02-5
Molecular Formula	C₁₄₆H₂₄₁N₄₃O₄₇S₂
SMILES	NC([C@@H]1CCCN1C([C@@]([C@H](O)C)([H])NC(CNC([C@@H](NC(CNC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@@]([C@H](O)C)([H])NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@H](CC3=CC=C(O)C=C3)NC([C@@]([C@H](O)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCCCN[H])NC([C@H](CC4=C
Molecular Weight	3414,9
Formulation	A solid
Purity	≥95%
Custom Code	2937.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.