R1487 (hydrochloride)

R1487 (hydrochloride)

CAT N°: 31478
Price:

From 55.00 46.75

R1487 is an inhibitor of p38? MAPK (IC50 = 10 nM).{33190} It is selective for p38? over p38? MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by greater than 85% at 10 µM. R1487 inhibits LPS-induced IL-1? production in isolated human whole blood (IC50 = 170 nM). It also inhibits LPS-induced production of TNF-? and IL-6 in rats (ED50s = 0.8 and 0.4 mg/kg). R1487 reduces yeast-induced hyperalgesia in rats (ED50 = 5.5 mg/kg).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-pyrido[2,3-d]pyrimidin-7(8H)-one, monohydrochloride
  • Correlated keywords
    • 449811-92-1 R-1487 p-38? 38? p38-? ? IL1? TNF? IL6 Lipopolysaccharide
  • Product Overview:
    R1487 is an inhibitor of p38? MAPK (IC50 = 10 nM).{33190} It is selective for p38? over p38? MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by greater than 85% at 10 µM. R1487 inhibits LPS-induced IL-1? production in isolated human whole blood (IC50 = 170 nM). It also inhibits LPS-induced production of TNF-? and IL-6 in rats (ED50s = 0.8 and 0.4 mg/kg). R1487 reduces yeast-induced hyperalgesia in rats (ED50 = 5.5 mg/kg).

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