GAD65 Monoclonal Antibody

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Cat No: 31360

Glutamic acid decarboxylase 65 (GAD65), also known as GAD2, catalyzes the production of GABA from L-glutamic acid and is encoded by GAD2 in humans.{61314} It is primarily expressed in pancreatic islets but is also expressed in neurons of the central a...

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Territorial Availability: Available through Bertin Technologies only in France

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GAD 65 2

Product Overview:
Glutamic acid decarboxylase 65 (GAD65), also known as GAD2, catalyzes the production of GABA from L-glutamic acid and is encoded by GAD2 in humans.{61314} It is primarily expressed in pancreatic islets but is also expressed in neurons of the central and peripheral nervous systems and is localized to vesicular membranes.{61314} Autoantibodies against GAD65 have been found in patients with type 1 diabetes mellitus or gestational diabetes mellitus and have been used as biomarkers of type 1 diabetes mellitus.{61314} GAD65 autoantibodies have also been found in patients with the rare neurological disorder stiff-man syndrome or autoimmune epilepsy.{61315,57555} Cayman’s GAD65 Monoclonal Antibody can be used for ELISA and Western blot (WB) applications. The antibody recognizes GAD65 at 65.4 kDa from human and mouse samples.

Size	100 µg
Shipping	dry ice
Host	Mouse
Antigen	Full-length recombinant human GAD65
Clone	9B10
Isotype	IgG1
Application(s)	ELISA, WB
Formulation	100 µg of protein G affinity-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.