From €102.00 €86.70
Thonzonium is a monocationic surfactant with diverse biological activities.{53955,53956,53957,53958} It is an inhibitor of F. tularensis acid phosphatase B (AcpB; Ki = 0.59 µM) and the vacuolar ATPase (V-ATPase) proton pump in C. albicans (EC50 = 69 µM in purified vacuolar membrane vesicles).{53955,53956} Thonzonium (25-400 nM) inhibits osteoclastogenesis induced by RANKL in bone marrow-derived macrophages (BMDMs) and inhibits bone resorption by mature osteoclasts in a V-ATPase-independent manner when used at concentrations of 100 and 200 nM.{53957} It prevents bone loss induced by LPS in a calvarial osteolytic mouse model when administered at a dose of 5 mg/kg per day. Thonzonium induces mortality in the helminths C. oncophora, O. ostertagi, H. contortus, and T. circumcincta with EC50 values of 4.5, 10.8, 5.1, and 6.7 µM, respectively, but is cytotoxic to HEK293 and RAW 264.7 cells with CC50 values of 9.2 and 5.7 µM, respectively.{53958} Formulations containing thonzonium as a surfactant have been used in the treatment of external auditory canal infections, as well as mastoidectomy and fenestration cavity infections.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 100 mg, 25 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 553-08-2 |
| Molecular formula | C32H55N4O • Br |
| Smiles | C[N+](C)(CCN(C1=NC=CC=N1)CC2=CC=C(OC)C=C2)CCCCCCCCCCCCCCCC.[Br-] |
| Molecular weight | 591,7 |
| Custom code | 2933.59 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is...
CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells.{59706,59704} It...
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
Headquarters:
Parc d’activités du Pas du Lac
10 bis avenue Ampère
78180 Montigny le Bretonneux
France
Copyright © 2024 BERTIN BIOREAGENT. All rights reserved | Terms & conditions
