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ATI-2341 (trifluoroacetate salt)

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    ATI-2341 (trifluoro<wbr/>acetate salt)
  • ATI-2341 (trifluoro<wbr/>acetate salt)
Cat No: 30990
Biochemicals - Receptor Pharmacology
Cayman

ATI-2341 is a pepducin Gαi-signaling biased agonist of chemokine (C-X-C motif) receptor 4 (CXCR4).{61067} It induces dissociation of Gαi and Gγ2, indicating activation of Gαi-signaling, with an EC50 value of 0.21 µM in a bioluminescence resonance ener...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-?-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine, trifluoroacetate salt
Correlated keywords:
  • TFA 1337878-62-2 ATI2341 CXC CXCR 4 G ? ? i 13 bio luminescence ? arrestin2 Tcells HEK 239 T chemo taxis GRK 2 3 CCRFCEM poly morpho nuclear
Product Overview:
ATI-2341 is a pepducin Gαi-signaling biased agonist of chemokine (C-X-C motif) receptor 4 (CXCR4).{61067} It induces dissociation of Gαi and Gγ2, indicating activation of Gαi-signaling, with an EC50 value of 0.21 µM in a bioluminescence resonance energy transfer (BRET) assay using HEK293T cells expressing CXCR4. ATI-2341 is selective for Gαi over Gα13 (EC50s = 0.53 and >1 µM, respectively, in BRET engagement assays) and is biased for Gαi engagement over β-arrestin-2, G protein-coupled receptor kinase 2 (GRK2), or GRK3 recruitment, exhibiting bias factor values of 24, 24.9, and 30, respectively. It induces chemotaxis of CCRF-CEM T cells, which endogenously express CXCR4, in a concentration-dependent manner. ATI-2341 (0.45 µmol/kg) increases peritoneal lavage fluid infiltration of polymorphonuclear leukocytes (PMNs) in mice.{61068}
Size 500 µg
Shipping dry ice
Molecular Formula C104H178N26O25S2 • XCF3COOH
SMILES O=C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)[C@@H](NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCSC)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC(O)=N)NC([C@@H](NC(CNC([C@H](CCSC)NC(CCCCCCC
Molecular Weight 2256,8
Formulation A crystalline solid
Purity ≥98%
Custom Code 2924.29
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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